Thursday, January 31, 2013

RNA Fragments May Yield Rapid, Accurate Cancer Diagnosis

Fragments of RNA that cells eject in fatty droplets may point the way to a new era of cancer diagnosis, potentially eliminating the need for invasive tests in certain cases. Cancer tumor cells shed microvesicles containing proteins and RNA fragments, called exosomes, into cerebral spinal fluid, blood, and urine. Within these exosomes is genetic information that can be analyzed to determine the cancer?s molecular composition and state of progression. Researchers at Massachusetts General Hospital discovered that exosomes preserve the genetic information of their parent cells in 2008, however exosomes have not seen widespread clinical testing as a means of cancer diagnosis until now. ?We have never really been able to detect the genetic components of a tumor by blood or spinal fluid,? says Harvard University neurologist Fred Hochberg. ?This is really a new strategy.? He says exosome diagnostic tests could potentially detect and monitor the progression of a wide variety of cancers. He is one of the lead researchers in a multicenter clinical study using new exosomal diagnostic tests developed by New York City-based Exosome Diagnostics to identify a genetic mutation found exclusively in glioma, the most common form of brain cancer. When treating other forms of cancer, surgeons are able to biopsy tumors to diagnose and monitor the state of the disease. For brain cancers like glioma, however, multiple biopsies can be life threatening. Bob Carter, head of neurosurgery at the University of California, San Diego, says well-preserved RNA in blood and spinal fluid enables researchers to test and monitor for these genetic changes noninvasively. He says study researchers separate exosomes from bio-fluids with a diagnostic kit and then extract the relevant genomic information. Once the specific cancer mutation is identified, clinicians will periodically draw additional bio-fluids to monitor the mutation levels to determine whether a patient is responding to therapy.?? Whereas Magnetic Resonance Imaging (MRI) is a useful tool, tumors only show up on imaging scans once they are at least one millimeter in diameter and comprise about 100,000 tumor cells. By that time, it may be too late for an early intervention. On the flip side, MRIs can also yield false positives. Hochberg says individuals who have been treated with conventional radiation therapy often have benign residual tissue from dying tumor cells that have been killed by the treatment but which the body has not yet eliminated. This tissue is often mistaken for tumor growth on a MRI scan. ?You would identify to the patient that the drug is not working when in reality it is doing well,? Hochberg says. ?On the other hand, having an easily accessible biomarker for glioma would give you a clear response.? There are 18 U.S. hospitals participating in the clinical trial, sponsored by the Accelerated Brain Cancer Cure Foundation. Hochberg says study researchers have recruited 41 of 120 patients so far. Preliminary results will be presented in April at the International Society for Extracellular Vesicles Symposium in Boston. From a technical standpoint I don?t believe there is a barrier,? Carter says. ?This test can certainly be used now, what we are trying to finalize is the sensitivity and specificity of the test.? Exosomes may be a reliable method of screening for prostate cancer as well. A PSA test is currently the most common, noninvasive means to screen for prostate cancer in the U.S. PSA testing measures for elevated levels of prostate-specific antigen, a protein produced by the prostate gland that is used to liquefy semen in men. The higher a man?s PSA level, the more likely it is that he has prostate cancer, says James McKiernan, director of urologic oncology at Columbia University Medical Center. There are additional reasons, however, for high PSA levels-and some men with prostate cancer do not always have elevated PSA, he added. In addition, for many cases of prostate cancer, new research published in May 2012 in The New England Journal of Medicine shows that treatment does not actually extend the life of the patient. ?Honestly PSA is not cancer-specific,? says Sudhir Srivastava, head of the National Cancer Institute?s Cancer Biomarkers Research Group. ?Exosomes could be very much [more] cancer specific. PSA might give you one specific biomarker for cancer identification, but exosomes can give you an entire disease specific profile so you would know whether or not it is a form of prostate cancer that necessitates treatment.? Researchers at Exosome have developed a diagnostic kit for prostate cancer with a diagnostic accuracy of around 75 percent-a rate comparable with that of actually taking a tissue biopsy, says Wayne Comper, a renal physiologist and chief science officer at Exosome. He says the first diagnostic kit could be available commercially by the end of 2013. Researchers use the kit to look for the genetic biomarker TMPRSS2:ERG or T:E in exosomes taken from a urine sample. Comper says levels of T:E are nine times higher in a cancerous prostate versus a healthy one. McKiernan says researchers found these exosomal diagnostic tests gave better predictive results for cancer than current prescreening methods, such as PSA. PSA levels are measured via a blood draw but also require a visit to a doctor?s office for a digital rectal exam, something that isn?t necessary with an exosomal diagnostic test. ?Our study got enough interest to put together a series of sites for investigation to lead to potential FDA approval of this particular kit,? he says. ?That is ongoing right now and the last time I checked there were about 1,000 patients who have been enrolled in the study.? Srivastava says Exosome's prostate kit could prove to be extremely relevant in cancer treatment if it survives the U.S. Food and Drug Administration?s grueling approval process. He says it is a precursor to what he hopes will be a series of multiple-gene-signature cancer tests. ?We are looking for something with about 90 percent accuracy before it can be used by itself for clinical diagnosis,? he says. ?NCI has done two prostate trials with exosomes to date and is looking into creating standard isolation procedures to make the tests more specific.? In the meantime Srivastava says exosomal tests could be used in conjunction with current methods of diagnosis like PSA to help physicians better determine if the nature of a prostate tumor is severe enough to warrant radical treatment or removal without ever performing a biopsy. ?If someone has high PSA and also has biomarkers which are positive in exosomes that would be a great test,? he says. ?Exosomes have the potential to really further the detection of cancer and help analyze things that would have otherwise not been detected noninvasively.? ? Follow Scientific American on Twitter @SciAm and @SciamBlogs. Visit ScientificAmerican.com for the latest in science, health and technology news.
? 2013 ScientificAmerican.com. All rights reserved.

Source: http://news.yahoo.com/rna-fragments-may-yield-rapid-accurate-cancer-diagnosis-213000243.html

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Hot Dog Marketing Online - ShoeMoney Internet Marketing Blog

A lot of people call me ?The Hotdogman.? I got my nickname from working in the food business, just like Shoemoney. Last week, all the buzz at Affiliate Summit West was about Shoemoney?s book, Nothing?s Changed But My Change, The Shoemoney Story. I picked one up at the Summit and read it on my flight home, it was a pretty good read and a great American Dream kind of tale. I met up with Jeremy on the exhibit hall floor and we had a chat. As it invariably does, the conversation swung around to hot dogs. Since I am The Hotdogman, I guess that?s a good thing; I have branded myself well in the internet marketing world.

As we were talking, Jeremy remarked that being a hot dog vendor and an internet marketer have a lot of similarities. We tossed that idea around for a minute or two, and the more I thought about it, the more I thought he was right. I was a hot dog truck owner and operator for 6 years and I started fiddling around with blogs, the internet, and affiliate marketing back in 2007 when a particularly harsh winter kept the truck closed for a few months.

That?s when I started The Hot Dog Truck, a blog about ?the life and times of a Hotdogman.? I started monetizing my site with Adsense (thanks in part to a certain blogger?s famous photo), did a lot of paid posting, and began experimenting with affiliate marketing. My wife thought I was wasting my time, but she changed her tune when I used my first few months blog earnings to take the family to Las Vegas to visit her folks! She?s been on board with my ?online thing? since. Six years later, the hot dog truck is gone, but the website remains. I also have a stable of 20 or so niche sites and I do freelance writing.

Hot Dogs and Marketing

My transition from hot dog man to The Hotdogman online was fairly easy, I have always been a decent writer and I was in sales since I was ten years old. Marketing online was understandable and doable for me. I decided to give the internet marketing thing a serious whirl when a series of bad luck left me essentially disabled for nearly a year; I got Lyme Disease, bad blood clots, and I broke my knee! The immobility this caused lent itself to spending my days at the computer. I sold my hot dog truck and dove right in to creating websites and marketing various products online.

My first ventures were geared toward what I know, most notably hot dogs. I sold hot dog related courses and products across a series of websites with success. When I was doing this, I?d think back to what made me successful in the hot dog business and applied what I could. The most notable similarity between online marketing and selling hot dogs is the autonomy for the entrepreneur. Both businesses can be one man (or one woman) ventures. As many people who read this know, there is nothing quite like working for yourself. You don?t have to answer to a boss, you do things your own way, and you reap all the financial rewards from your ventures.

Going into the hot dog business is a low investment proposition. Even a shiny new hot dog cart can be bought for less than three grand; if you buy used, that number goes lower. Compared to opening a brick and mortar restaurant, starting up a hot dog cart is short money. The same is true for starting out in internet marketing. I got started with eight bucks and a free host. As time went on, I invested in premium WordPress themes, an email program, more domains, private servers, and other tools, but other than that first eight bucks, I never paid for any of that stuff ?out-of-pocket.? Investments into my growing online ?empire? always came from profits. I don?t know any other legitimate business you can start for eight bucks!

The Hot Dog Cart Principle in Online Marketing

Starting in the hot dog business is a bit more complicated than buying a cart, setting up shop, and hanging out a sign. There are some regulations involved and you need the appropriate permits. You also need to sell. If nobody knows you?re there, you won?t sell any hot dogs; you need to market your business. That involves getting out to the businesses nearby and giving them an incentive to stop by and try your chow. Theoretically, once someone takes a bite of your delicious hot dogs, they?ll tell their friends and co-workers and you?ll be off and running.

The same goes for online marketing. Like any business, there are rules and regulations to follow, so you need to know them before you get started. You could have the best offer or product in the world, but nobody will buy it unless they know about it. Just setting up a website and hoping won?t get you any sales. You need to use proven methods for generating traffic, the online equivalent of letting people know about your offer. Just like offering a free hot dog to get people to try you out, you can offer incentives to take a look at your offer. Think about it, how many free e-books have you downloaded? (I like mine with mustard and relish).

Whether you?re selling hot dogs or an online product, you still need to provide value to your customer. A good hot dog man will have premium hot dogs, fresh rolls and condiments, and he?ll serve them up HOT for a fair price. A good online marketer will have a quality offer or product that gives the customer what they?re looking for, whether it?s a product to solve a problem, an entertaining book, or a deal on the latest gadget, there has to be value for the customer at the right price or else you?re spinning your wheels.

Both businesses are scalable, too. I know many successful hot dog vendors who have moved on to managing multiple carts and trucks and even opened full-on restaurants. The concept is fairly simple and easily duplicated, you just need to find the right people. Online marketing is the same. Once you have a system and a set of processes in place, you can expand and duplicate your business. Hiring the right people is key here too. Make sure you hire and work with people who have complimentary skill sets. I started with one website, now I have more than 20 and I have people I call on for certain tasks that I just am not good at.

Notice in that previous paragraph ?the right people? came up a number of times. Whether you?re selling hot dogs or pitching the latest hot info product, having good people to work for/with you is key. A crappy employee can bring down any small business pretty quick if left unchecked. Whether that employee is serving food that?s under cooked or servicing online customers with an inconsistent attitude, the bad apple can be a killer. Conversely, good people can boost your business. An enthusiastic, friendly vendor brings people back to your cart. A savvy employee who ?gets out there? and helps boost business, whether it?s with good follow through or promotion through their social media networks, can be a great asset to any business.

Not ready to leave the security of a paycheck to start a business? Start part-time! Hot Dog vending can be started as a part time venture. Just work weekend events or find opportunities to set up shop within your existing schedule. The same goes for an online business. You can start on your living room couch! Spend a few hours a day building your business; you?ll know when you can transition to full-time in either venture.

Fun is Good too

Online marketing and hot dog vending are fun businesses. I was always cutting it up with my customers at my hot dog truck and I made many new friends in the six years I was in the business. Hardly a week goes by that I don?t run into an old customer. I?ve even made some good business connections from my old hot dog contacts! Online marketing is fun too. While many relationships are forged online, the same principles apply. Treat people well, be nice, offer good products and service and you?ll make new friends. The one thing online marketing has going for it in the fun department over the hot dog business is industry events. Parties at online marketing conferences ROCK! Hot dog events I?ve attended have been small; while they were fun and informative, there were never open bars in fancy nightclubs with go-go girls!

It all boils down to one thing: good old American entrepreneurship. Despite the woes afflicting our nation right now, entrepreneurship is alive and well in the US of A. Many of the hot dog vendors I encounter on a regular basis are in the business due to corporate downsizing. They chose the hot dog biz for many of the same reasons I listed here. The same goes for online marketing. Many people are content to moan about the economy and wring their hands in despair. The folks who decide to do something about it, whether they start slinging hot dogs or selling stuff online REFUSE to let macro circumstances dictate their future. No matter what the economy looks like, people still need a good, cheap lunch and they?ll continue to by all sorts of products online. Entrepreneurs who decide to capitalize on opportunities will always find success if they go about it the right way.

The most important thing any entrepreneur can do is get started NOW! No business gets started by thinking about it. If you want to sell hot dogs, start scouting locations, research carts, and learn about your business. If you want to get going in the online marketing game, start learning the basics (I hear Shoemoney has a course or two about that). You can have a website up in an hour or two. I know many online entrepreneurs who built a website in one night and were doing business the very next day. Don?t fall into the ?paralysis by analysis? trap, if you want to start a business, START NOW!


Jason recommends you check out these amazing posts:

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  3. Jeremy-Schoemaker-Speaking-Taj-Hotel-San-Francisco-ER8thumb How I Get The Most Out of Conferences

Source: http://www.shoemoney.com/2013/01/30/hot-dog-marketing-online

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Wednesday, January 30, 2013

GDP contracts on tepid inventories, government spending drops

WASHINGTON (Reuters) - The economy unexpectedly contracted in the fourth quarter, suffering its first decline since the recession ended more than three years ago as businesses scaled back on restocking and government spending plunged.

Gross domestic product fell at a 0.1 percent annual rate after growing at a 3.1 percent clip in the third quarter, the Commerce Department said on Wednesday.

That was the worst performance since the second quarter of 2009 and showed the economy entering the new year with no momentum, but economists cautioned against reading too much into the decline in output.

"You got a combination of inventories and defense which are taking more than 2 percentage points off the growth rate," said Nigel Gault, chief U.S. economist at IHS Global Insight in Lexington, Massachusetts. "This is not an indicator of recession."

Still, the contraction, coming against a backdrop of tightening fiscal policy, could create an urgency for policymakers to deal with outstanding budget issues.

Economists polled by Reuters had expected output to increase at a 1.1 percent rate. None of the economists surveyed had predicted a contraction.

A pick-up in consumer spending and a rebound in business investment curbed the slide in output and offered some hope for the recovery, which will be severely tested as Washington tightens its belt.

A second report showed private employers stepped up hiring in January, suggesting an improvement in the labor market. An increase in job gains could help the economy to weather the headwinds in the first half of the year.

The ADP National Employment Report showed private payrolls rose 192,000 in January after increasing 185,000 in December.

U.S. Treasury debt prices rallied on the GDP number, while the dollar fell. Stock futures extended losses.

The data were published as officials at the Federal Reserve wrap-up a two-day meeting. The report will likely provide ammunition for officials at the U.S. central bank to stay on their ultra-accommodative policy stance.

Economists say a growth pace in excess of 3 percent would be needed over a sustained period to significantly lower high unemployment. The economy has struggled to hold above a 2 percent growth pace.

For the whole of 2012 the economy grew 2.2 percent.

The economy was slammed by a monster storm in late October, which caused extensive damage along the East Coast, which was expected to have cut around 0.5 percentage point off fourth-quarter growth.

The recovery also had to deal with uncertainty over the so-called fiscal cliff of scheduled tax hikes and budget cuts, which hurt confidence even though data suggests that households and businesses largely shrugged off the worries.

SOME BRIGHT SIGNS

Businesses, caught with too much inventory in their warehouses in the third quarter, slowed their stock building in the final three months of the year.

That slowdown sliced 1.27 percentage points from fourth-quarter GDP growth. That was the biggest drag in two years. Excluding inventories, the economy grew at a 1.1 percent rate, slowing from the third quarter's 2.4 percent.

Government spending tumbled at a 6.6 percent rate, as defense outlays plunged at a 22.2 percent pace, wiping out the previous quarter's gains. Government subtracted 1.33 percentage points form growth. The decline in defense spending was the largest since 1972.

Export weakness also weighed on growth. Exports have been hampered by a recession in Europe, a cooling Chinese economy and storm and strike-related port disruptions. Overall trade cut a quarter of a percentage point from GDP growth. Exports fell for the first time since the first quarter of 2009.

But not all the details in the report were bleak.

Importantly, consumer and business spending showed some strength, and income available to households after taxes and inflation increased substantially in the fourth quarter.

In addition, the saving rate increased to 4.7 percent from 3.6 percent in the third quarter, which should support future spending.

Consumer spending, which accounts for more than two-thirds of economic activity, rose at a 2.2 percent rate, accelerating from the prior quarter's 1.6 percent growth pace.

Business investment rebounded after its first drop in 1-1/2 years in the prior quarter. The housing market was another bright spot. Residential construction grew at a 15.3 percent rate after notching a 13.5 percent growth pace in the third quarter.

Homebuilding added to growth last year for the first time since 2005.

(Additional reporting by Herb Lash and Leah Schnurr in New York; Editing by Andrea Ricci)

Source: http://news.yahoo.com/u-growth-seen-braking-inventories-government-weigh-060305476--sector.html

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Enhance Your Business Portfolio by Investing in Seo

The popularity of the internet and its applications are at its peak these days. Be it shopping, catching up with friends, running a business, learning something new or simply speaking your mind, you will find that internet offers all such solutions for free. Owing to its increasing craze, there are many business owners who have gone online to cater to a wide customer base. Whether you are a new business in the market or you have dwelled for decades, the need to go online is imminent and cannot be ignored.

But simply creating a website and launching it on the web does not turn the magic key. You need to put in some more efforts through advertising and marketing which will help you unleash the full potential of the web and it will make your business a success too. Hence, investing in marketing techniques like SEO is imperative and there are various sub categories of this method which you can make use of in order to increase customer attention. SEO stands for search engine optimization which theoretically means improving the rank of a website on search engines like Google, Bing and others.

If you are after SEO services in Sydney, there are a lot of providers out there which can easily help you with your needs. All you have to do is contact them, learn about the different services that they offer under SEO and go through their work profile once. This will help you understand the capability of the service provider and this way you will only invest in the best services. There is a lot to be done under SEO which is why you should choose to go for an exhaustive optimization bundle which would cater to all your needs.


When it comes to working on on-site SEO which would be for your website, you should make sure that the provider has worked on the keyword density of the content that you have put on your site. With this, they should also check for any broken links and any bugs which might hinder the crawlers to browse your site completely. Once this is done, it is time for off-site SEO which is accomplished by a variety of techniques like social bookmarking, article and blog submission and social media optimization. So choose to go with the best SEO services in Sydney and make your online business an easy success through proven online marketing methods.

Source: http://www.shvoong.com/internet-and-technologies/search-engine-and-seo/2354368-enhance-business-portfolio-investing-seo/

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Policeman protecting Pakistani polio team killed

PESHAWAR, Pakistan (AP) ? Gunmen riding on a motorcycle shot and killed a police officer protecting polio workers during a U.N.-backed vaccination campaign in northwestern Pakistan on Tuesday, the police said.

The attack took place as dozens of polio workers ? including several women ? were going door-to-door to vaccinate children in Gullu Dheri village of Swabi district in Khyber Pakhtunkhwa province, said senior police officer Izhar Shah. None of the polio workers the police officer was protecting were hurt in the attack, he said.

"The polio workers were terrified and immediately went back to their homes after the attack," Shah told The Associated Press. "The anti-polio drive in that village has been suspended."

Elsewhere in the northwest, a man wounded a polio worker, Mohammed Mumtaz, with an axe. Mumtaz was marking houses in Machi village to indicate where vaccines had been administered, he said. The attacker became irate after his door was marked and swung the axe at Mumtaz, injuring him on his left arm.

The attacks occurred on the second day of a three-day campaign against polio that was launched by the provincial government. No one claimed responsibility for the shooting in Gullu Dheri, but suspicion fell on militants.

Some Islamic militants oppose the vaccination campaign, accuse health workers of acting as spies for the U.S. and claim the polio vaccine is intended to make Muslim children sterile.

Suspicion of vaccination campaigns heightened considerably after it became known that a Pakistani doctor helped in the U.S. hunt for Osama bin Laden.

The physician, Shakil Afridi, ran a hepatitis vaccination campaign on behalf of the CIA to collect blood samples from bin Laden's family at a compound in Abbottabad in Pakistan's northwest, where U.S. commandos killed the al-Qaida leader in May 2011.

The samples were intended to help the U.S. match the family's DNA to verify bin Laden's presence in the garrison city.

In the recently-released film "Zero Dark Thirty" about the search for bin Laden, a short scene shows a man going to the compound where bin Laden was hiding as part of a vaccination campaign. But in the movie, it's portrayed as an anti-polio campaign instead of anti-hepatitis.

In December, gunmen killed nine polio workers in similar attacks across Pakistan, prompting authorities to suspend the vaccination campaign in the troubled areas. The U.N. also suspended its field operations in December as a result of the attacks. They have since resumed some field activities, said Michael Coleman, a spokesman with UNICEF's polio campaign.

The latest campaign in Khyber Pakhtunkhwa was launched Monday to give oral drops to those children who had missed it the first time round.

Pakistan is one of only three countries where the crippling disease is endemic. The virus usually infects children living in unsanitary conditions; it attacks the nerves and can kill or paralyze. As many as 56 polio cases were reported in Pakistan during 2012, down from 190 the previous year, according to the United Nations.

Most of the new cases in Pakistan were in the northwest, where the presence of militants makes it difficult to reach children.

Pakistan is also struggling to maintain control of its southern province of Baluchistan.

On Tuesday, gunmen driving in a car opened fire on two police constables who were patrolling on motorcycle in a neighborhood of the provincial capital, Quetta, said Nadir Khan, a local police chief. Both the police officers were killed instantly, he said.

There was no immediate claim of responsibility but similar attacks against security forces are believed to be the work of Baluch nationalists who have been pushing for a greater say in how the province's resources are dispersed.

__

Associated Press writer Zarar Khan contributed to this report.

Source: http://news.yahoo.com/policeman-protecting-pakistani-polio-team-killed-120627955.html

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Tuesday, January 29, 2013

Savior One

Savior One

When faced with an overwhelming threat, the great nations of the world present their last hope.

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This topic is an Out Of Character part of the roleplay, ?Savior One?. Anything posted here will also show up there.

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
This is the auto-generated OOC topic for the roleplay "Savior One"

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Seveneleven
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Forbes: Man U first team worth over $3B

updated 6:36 p.m. ET Jan. 28, 2013

(Reuters) - English Premier League soccer club Manchester United are the world's first professional sports team to be valued at more than $3 billion, according to Forbes Magazine.

A recent surge in the club's shares after a poor start when they were offered on the New York Stock Exchange last year has boosted Manchester United's value to $3.3 billion, a report on Forbes's website said on Monday.

The increase has United, English champions a record 19 times, comfortably ahead of the world's second-most valuable sports team, the National Football League's Dallas Cowboys, worth $2.1 billion.

Forbes put the surge in United shares down to brighter earnings prospects from new sponsorship deals and said the demand could continue given the team's potential for lucrative payouts in the EPL and Champions League.

United, who claim to have 659 million followers worldwide, are owned by the American Glazer family who retained a tight grip on the club after the flotation on the New York Stock Exchange.

United shares closed 41 cents lower at $16.48 in New York on Monday.

(Reporting by Frank Pingue in Toronto; Editing by Ian Ransom)

(c) Copyright Thomson Reuters 2013. Check for restrictions at: http://about.reuters.com/fulllegal.asp


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PST: Jurgen Klinsmann's seemingly harsh motivational tactics appear designed to make national team members, like Mix Diskerud, ask themselves, "Where will you take it from here?"

Source: http://nbcsports.msnbc.com/id/50620810/ns/sports-soccer/

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Immediate, adjuvant ADT after surgery does not significantly affect ...

Posted on by Sitemaster

For many years, physicians at the Mayo Clinic in Rochester, MN, have been offering immediate, adjuvant androgen deprivation therapy (ADT) to some of their surgical patients with more advanced and high-risk forms of prostate cancer. The assumption had been that early use of ADT among such patients might have a significant survival benefit.

Linder et al. have now published a detailed, retrospective analysis of the outcomes of 1,247 men, all treated by radical prostatectomy for high-risk prostate cancer between 1988 and 2004. High-risk disease was defined by the criteria of the National Comprehensive Cancer Network and therefore implied at least one of the following: clinical stage ? T3a or a Gleason score of ? 4 + 4 = 8 or a PSA level > 20 ng/ml. All patients were also categorized by comorbidity status through the use of the Charlson comorbidity index.

The investigators? intent was to evaluate whether the use of immediate, adjuvant ADT had any beneficial impact on overall or prostate cancer-specific survival when the patients were stratified by comorbidity status.

Here is what they found:

  • 419/1,247 patients (33.6 percent) were treated with immediate, adjuvant ADT after surgery.
  • 828/1,247 patients (66.4 percent) were not treated with immediate, adjuvant ADT after surgery.
  • The average (median) age of the patients was 65 years.
  • 816/1,247 patients (65.4 percent) had a Charlson comorbidity index of 0.
  • 244/1,247 patients (19.6 percent) had a Charlson comorbidity index of 1.
  • 142/1,247 patients (11.4 percent) had a Charlson comorbidity index of 2.
  • The 10-year overall survival data for the patients, when stratified by Charlson comorbidity index, was as follows:
    • 75 percent for men with a Charlson score of 0 who received immediate, adjuvant ADT.
    • 82 percent for men with a Charlson score of 0 who did not receive immediate, adjuvant ADT.
    • 72 percent for men with a Charlson score of 1 who received immediate, adjuvant ADT.
    • 76 percent for men with a Charlson score of 1 who did not receive immediate, adjuvant ADT.
    • 70 percent for men with a Charlson score of ? 2 who received immediate, adjuvant ADT.
    • 68 percent for men with a Charlson score of ? 2 who did not receive immediate, adjuvant ADT.
    • None of these differences is statistically significant.
  • 155/1,247 patients (1.4 percent) had cardiovascular disease.
  • The 10-year overall survival for patients with cardiovascular disease was as follows:
    • 72 percent for men who received immediate, adjuvant ADT.
    • 76 percent for men who did not receive immediate, adjuvant ADT.
    • This difference, again, was not statistically significant
  • On multivariate analysis, receipt of immediate, adjuvant hormonal therapy ADT post-prostatectomy was not associated with non-prostate cancer mortality (P?=?0.24).

The authors conclude that, in their long series of patients with high-risk disease, the use of immediate, adjuvant ADT? after radical prostatectomy does not increase the probability of death from something other than prostate cancer ? even when the patients have multiple comorbidities.

Now it has to be remembered that this was an open study of a series of patients, not a clinical trial, and that the analysis is retrospective as opposed to prospective, so one would be wise not to over-interpret the results presented above. On the other hand, there is little to no indication from this series of data that early use of ADT in high-risk men after radical prostatectomy even might be capable of inducing a meaningful survival benefit.

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Source: http://prostatecancerinfolink.net/2013/01/28/immediate-adjuvant-adt-after-surgery-does-not-signifciantly-affect-survival-if-high-risk-men/

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MintLife Blog | Personal Finance News & Advice | Can I Dispute ...

question

I received the following question from a Minter via the Mint.com Facebook page:

Question: ?John, I just got all of my credit reports for free and there are some items that are old, accurate, and just downright bad. I?d love to get rid of them. The materials that came with the credit reports make it pretty clear that I can dispute information that?s incorrect and get it corrected.

But I have a different dilemma: I have information that I know is correct that I?d like to get removed. Is there any downside to disputing information on a credit report that you know to be accurate? Can I get in trouble??

Answer: First things first, the Fair Credit Reporting Act gives each of us the right to challenge information on our credit reports with which we don?t agree. There?s nothing in that law that prohibits consumers from disputing information on their credit reports for any reason.

Further, ?accurate or inaccurate? is not the only variable that can cause the credit reporting agencies to remove something from a credit report. Your credit report information must be able to be verified, right or wrong.

So, if you disputed something from your credit reports and the furnishing party failed to respond to the credit bureaus, the item would be deemed unverifiable and would be removed.

It may have been perfectly accurate, but because the lender couldn?t or wouldn?t confirm its accuracy ? bye, bye negative information!

Is it wrong to dispute correct information?

I?m not the morality police, and you can do what you want to do, but you do have the right to challenge any information on your report ? whether it?s correct or not.

It?s your right to have correct and verifiable information on your credit reports.?I can?t speak for them, but I imagine they?d also want your credit report to be fully accurate and verifiable.

How to file disputes with the credit bureaus

If you do file disputes with the credit bureaus, you should think about how to word your letter. I?m not sure I?d go so far as to tell them you want accurate information removed. I?d simply ask that they verify what?s already being reported.

After you file your dispute, the credit bureaus will contact the furnishing party, normally a lender or a collection agency. These parties are formally referred to as ?data furnishers? or ?furnishers? for short.

It?s their responsibility to investigate your claim and get back to the credit bureaus, normally within 30 days, but there are some scenarios when it can take 45 days.

If they confirm the accuracy of the credit reporting, then you?ll likely have to live with it until the credit bureaus have to remove the item, which normally takes 7 years for the bad stuff.

How to re-dispute an item

You can certainly choose to re-dispute the item with the credit bureaus. They?ll likely send another dispute form (called an ?ACDV?) to the furnisher asking them to investigate the item again.

However, unless you?ve contacted the furnisher and convinced them that it?s wrong, they?ll likely send the same response to the credit bureaus.

If you choose to dispute the item again, you should be aware that the credit bureaus do not have to honor your request unless you provide some new information.

The Fair Credit Reporting Act allows the bureaus to consider repetitive disputes to be frivolous and ignore them.

Do you have a credit questions for John Ulzheimer? Head over to the Mint.com Facebook page and ask away!

John Ulzheimer?is the President of Consumer Education at?SmartCredit.com, the credit blogger for?Mint.com, and a contributor for the?National Foundation for Credit Counseling.? He is an expert on credit reporting, credit scoring and identity theft. Formerly of FICO, Equifax and Credit.com, John is the only recognized credit expert who actually comes from the credit industry. The opinions expressed in his articles are his and not of Mint.com or Intuit.?Follow John on Twitter.

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Source: http://www.mint.com/blog/credit/can-i-dispute-negative-information-on-my-credit-report-even-if-its-correct-0113/

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Monday, January 28, 2013

Cyhi The Prynce Gives Feel G.O.O.D. Music On Ivy League: Kick Back

'You can party to it; you can chill to it; you can ride to it,' Atlanta MC tells Mixtape Daily of his latest project, which drops Tuesday.
By Rob Markman, with reporting by FLX


Cyhi the Prynce
Photo: MTV News

Source: http://www.mtv.com/news/articles/1700872/cyhi-the-prynce-ivy-league-kick-back.jhtml

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Obama honors NBA Champion Miami Heat

WASHINGTON (AP) ? President Barack Obama honored the Miami Heat for winning the 2012 NBA Championship title after falling short just a year before.

"Everybody doing their part, is what finally put the Heat over the top," Obama said, as he welcomed the team to the White House Monday to celebrate their victory.

The Heat defeated the Oklahoma City Thunder in five games in the NBA Finals last June.

The president also recognized the franchise's work off the court. He thanked them for supporting military service members at Walter Reed National Military Medical Center. Obama said one of the things he's proudest of is that many of the team members? including LeBron James, Chris Bosh and Dwyane Wade? "take their roles as fathers seriously."

"For all the young men out there who are looking up to them over time, for them to see somebody who cares about their kids and is there for them, day in, day out, that's a good message to send," Obama said.

Miami Heat coach Erik Spoelstra said the team hopefully will serve as an inspiration to the nation of what can be done "when you come together and sacrifice your egos for a greater goal" and "hard-hat work ethic."

James, who presented Obama with an autographed basketball, said the team including members that hail from Illinois, Texas, Michigan, Ohio and South Dakota were honored to be in the executive mansion.

"We're in the White House right now, which is like, like 'mama I made it,'" James said, as the audience laughed and cheered.

The crowd of well-wishers included actress Gabrielle Union, U.N. ambassador Susan Rice, U.S. Education Secretary Arne Duncan and Congresswoman Debbie Wasserman Schultz. The Heat last visited the White House after winning the 2006 title.

Source: http://news.yahoo.com/obama-honors-nba-champion-miami-heat-193857315--politics.html

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Changing Universities: A University without Faculty: The Demise of ...


The University of Phoenix is now the largest university in America, but this may soon change. This mostly online institution is facing an accreditation sanction, which could force it to lose its Pell Grants, student loans, and other federal subsidies. Not only is the stock price taking a major beating, but massive layoffs are underway.

Although we should not take enjoyment in other people?s job losses, it is important to focus on what happens when higher education is taken over by a soulless corporation. As the founder of the university has become a billionaire and has just received a $5 million retirement package, the school is shedding many of its on-the-ground employees. Like many other for-profit schools, the U. of Phoenix receives most of its funding from public monies, and then uses these funds to enrich administrators and shareholders and hire an army of marketers and recruiters in order to turn mostly under-represented minority students into unemployed debt slaves, and they do this by hiring all of their faculty off of the tenure system. In many ways, this school represents the extreme logic of the online education movement: eliminate tenure for the faculty, develop questionable distance education, cater to private corporations, and make students suffer with high debt levels and bogus degrees (actually very few students ever get their degrees, and very few get their promised jobs).

While online course providers like Coursera and Udacity appear to represent a much more progressive version of this high-tech education promotion, let us look at some of the statements that are coming out of the mouths of these not-for-profit, profit-seeking marketers. Here is Sebastian Thrun, founder of Udacity, from the UCLA forum (these quotes come from the rush transcript on Remaking the University): ?Students rarely learn listening . . . or they never learn by listening. The challenge for us is to take this new medium and really bring it to a mode where students do something and learn by doing. And if you look at the broad spectrum of online technology with what happens. It doesn?t really take long time to point to video games. And most of us look down on video games. We?ve also played them. I know there are people in this room who play angry birds. Some people do. Some people don?t admit it. Angry birds is an wonderful learning environment because you get drawn in, you solve the physics problems but the big problem is that it stops at angry birds . . . if the angry birds was good enough to get into the masters students in physics. It would be an amazing experience and you could do this at scale.? The point I want to stress here is the claim that students never learn from listening. Following this logic, most of current education is simply useless, and we should just have students take out their smart phones and play Angry Birds all day.

During Thrun?s presentation at UCLA, this downgrading of traditional learning environments was connected to a downsizing of the faculty: ?As we know that higher education is moving at a slower pace compared to the industry moves. We have been funded by a whole bunch of corporations that make the classes with us and there?s a number of classes launching soon on topics to be not covered in academia. If you look at the way the technology turns over, it will be 5-10 years in computer science [and] if you look at the way colleges turn over, it?s much more difficult because [with] tenure they are gonna be with us for 30 years so the national turnover rate for colleges is about 30 years. Industries it?s like 5-10 years. So there?s a disconnect between how the world changes and how colleges are able to keep up. Therefore in computer science it would be hard to find courses that teach technologies that are useful today such as IOS and all the wonderful things that they do. So the industries jumped in and funded us to build these classes.? According to this logic, since tenure requires a thirty-year commitment to the faculty, and industry and technology change at a much faster rate, we need to get rid of the secure faculty and replace them with student mentors and the latest technology.

Thrun?s argument fails to recognize that faculty also develop and change, and most faculty, including his own wife, now teach without tenure. His point of view also pushes the idea that technological change is always for the better, and even if it is not good, there is no way to resist it. As I have previously argued, we need to compare online courses to our best courses and not our worst, and we have to defend and define quality education and push for more funds to be spent on small, interactive classes. However, Thrun and other MOOC celebrators appear to have a disdain for their own teaching: ?But in the existing classes, the level of services are often not that great. . . .I talked to numerous instructors and you divide the time the communal time and the personal time you give back to the students in terms of advising and grading . . . you can be lucky as a student for 3 credits class to get 3 hours of personal time. Many people laugh and many say I spend 10 min/student per class and the rest I give to my TAs. Charging $1,000-$4,000 for that to me is gonna be a question going forward.? Although I have often questioned what students are actually paying for in higher education, what Thrun is really questioning is the validity and value of large, impersonal lecture classes, and on this point, we are in agreement; still the question that remains is if large online courses can really provide the quality education they advertise.

At the last Regents meeting, many of these themes were continued as three computer science professors attempted to convince the UC system that online courses would make higher education ?better, faster, and cheaper.? In her presentation for Coursera, Daphne Koller insisted that since students now have a very short attention span, the classic lecture has to be broken up into a series of short videos followed by an interactive question and answer system. She argued that this method paradoxically makes mass education personalized as it pushes students to constantly learn and be tested on material before they advance. This type of ?drill-and-skill? education is very similar to how computer science classes are often currently taught, so it should not surprise us that all of the presenters were computer scientists. Yet, we must question whether all classes can and should be taught like a computer science course.

Like the other online course providers, in order to differentiate her ?product? from the ?traditional? model of education, Koller had to constantly put down the current way we educate students. Thus, she derided the ?sage on the stage? and the inability of most students to ask questions in their large lecture classes. She also bemoaned the fact that no one wants to read students? tests with identical questions and answers, and so the whole grading process can be given to computers and fellow students. Once again, this argument not only degrades the value and expertise of faculty, but it also treats students as if they need to be reimagined as programmable machines and free laborers. Yes, let?s have the students? grade each other?s paper, and while they pay for their education, let us train them to work for free.

Another alarming aspect of the rhetoric of these providers is their constant reference to experimenting on students as they attempt to increase access to higher education. The idea presented at the Regents meeting is that since so many under-represented students cannot find places in the UC system, these students from underfunded high schools should be given an online alternative. Some have called this the Digital Jim Crow because wealthy students will still have access to traditional higher education, while the nonwealthy, under-represented minority students will be sent to an inferior online system. Of course this new form of educational segregation is being pushed under the progressive banner of expanding access.

Source: http://changinguniversities.blogspot.com/2013/01/a-university-without-faculty-demise-of.html

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Sunday, January 27, 2013

6 Ways To Create A World Famous Money Making Podcast ...

Create A PodcastHow do I create a podcast and make money? Nowadays this question is becoming more and more popular. If you have ever listened to, or subscribed to, a podcast, then you already know how convenient they are. You simply subscribe to the podcast, and it is downloaded as updates are available. Then, you can listen to the podcasts at your convenience, regardless of whether you are online or offline.

So, given the popularity of podcasts, have you ever considered the idea of creating your own podcast? If not, perhaps you should. The podcast has truly liberated the notion of free broadcasting in that anyone with the right equipment (which usually costs less than a few hundred dollars, not including internet access) can broadcast online.

Just as with any other endeavor, there are steps that the experts recommend be implemented before the first episode.

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How To Podcast Like A Pro

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1 ? Plan Your Podcast

Create Podcast Notes

When creating a podcast, as tempting as it may be to jump in, feet first, it is always best to plan ahead and organize. Know your topic, and organize the material well so that it flows naturally. Failure to plan will make your podcast seem awkward, lack direction, and will lose listeners very quickly. It is a good idea to choose a topic that you are passionate about, as you are more likely to convey your enthusiasm about a topic that captures your own interest. In turn, it will capture the interest of others.

Write out a few dot points on some subjects you would like to cover over the course of the cast, that way you stay on track and your audience will not get lost in your discussion.

(Image Courtesy of?Cam Knows)

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2 ? Set The Stage

How To Create A PodcastIn podcasting, ?setting the stage? is a metaphor for deciding how your podcast is going to be formatted. Will you be speaking alone? Will you be engaging in dialogue with someone else? Will you be adding music to enhance the podcast? The possibilities are only limited by the boundaries of your imagination. There are no legalities to restrict your creativity with one exception: if you do plan to use music in your podcast, make sure that you have all of the appropriate permissions from the artist(s) and recording companies. Or, if you have musical talent, you may simply create your own music.

Also, as a postscript to the legality of podcasts, common sense should come into play. Use of material that is illegal in nature is not encouraged and may result in criminal action being taken against you. Again ? just use common sense.

(Image Courtesy of Siamese Puppy)

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3 ? Create A Professional Recording Location

The volume of background noise that exists in our lives would probably amaze us if we really noticed it. As we live and grow in our surroundings, we learn to ?tune out? background noises and only notice noises if they are unusually loud, sudden, or strikingly different from the normal background noise that is always there.

To the contrary, when recording audio, every decibel of background noise is not only audible to the listener, it can be distracting and annoying. Furthermore, most normal rooms have a faint echo which is also magnified when recording.

When setting up your location for podcasting, the smaller the surroundings, the better. Also, having some sort of insulating surface around the recording area will help to absorb the sound of your voice and prevent the bounce-back effect of an echo. As strange as it may sound, a good way to practice podcasting is to do so in a clothes closet, as long as you are not claustrophobic. The surrounding clothing will absorb the excess noise and the improvement in voice quality will be significant. Once this has been completed as a test, strive to achieve similar quality in the broadcast location.

(Image Courtesy of?Travis Estell)

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4 ? Prepare Your Gear

Create Podcast In the StudioYou can get your hands on a fairly reasonable condenser studio mic for as little as $200 USD with a wind muff to stop those ?pff? sounds when you blow or speak loudly into the mic. It also pays to purchase an MBox or a good quality sound card for your computer, this will allow you to record your podcast in CD quality (320kbps). You will need a mixer to run your Mic?s through, just make sure the mixer has ?Phantom Power?, to power your condenser mic. A mixer is also great for expanding out the number of mic?s as you introduce more guests on your show.

You will need a nice set of Headphones,?preferably?the over ear ones and as far as software goes, you can use either Logic, Pro Tools or if you are on a pretty tight budget then ?Garage Band? will even do the trick. There are other multi track recording and editing programs but those three came to mind as a great tool for tracking your podcasts.

(Image?Courtesy?Of?mbrown)

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5 ? Create A Great Environment

Joe Rogan Podcast StudioMake sure your environment is as comfortable as possible and really set the scene, put up a funny poster ,an awesome view of Manhattan or a canvas print of Muhammad Ali knocking out his competition to inspire your thoughts while podcasting, it?s all really up to personal preference. Famous Podcaster, ?Joe Rogan? even has mannequins with ?Storm Trooper? helmets on them to jazz up his studio. Let your imagination run free and create a cool vibe in the room.

The more professional and personalised the setup, the more serious you will take your podcasting.

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6 ? Promote Your Podcast

Social Media PodcastingThis part is just as important as creating your podcast itself. How is anyone going to hear your podcast if you keep it all to yourself? Add a ?Get on Youtube, Twitter, Facebook, Google+ and start promoting your show and posting snippets of your clips. Create a community on Google+ that is aligned with what you talk about and start discussions with those like-minded people so that you can share your show with them also.

Most people will only listen to the first 30 seconds of a podcast, so make sure you are always giving your ?A! Game? and you are showcasing what you feel will be a highlight of what your podcast REALLY has to offer the world. If they like what they hear then they will listen, then hopefully share your podcast also with their Facebook friends and Twitter/YouTube followers.

All the pros are publishing their podcasts in the iTunes Store, the best way to do this would be:

Alternatively, you can navigate to the submission page this way:

  1. Open iTunes.
  2. Click the iTunes Store icon in the Source list.
  3. From the?Choose Genre?pop-up menu, choose?Podcasts.
  4. Click the big ?Publish a Podcast? button in the middle of the screen.

Note:?The iTunes team reviews each podcast submission. Depending on demand, it may take a week or two before your podcast is added.

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How Can You Make Money Podcasting?

Podcasting is a lucrative means of earning a solid income online. To effectively use podcasting to generate earnings, it is always a good idea to follow the examples of others who have been successful in an endeavor such as this. Some examples of successful podcasters include:

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The Joe Rogan ExperienceJoe Rogan,?a?UFC commentator, comedian?and?the host of?the hit TV show?Fear Factor?runs his own personal podcast ?The Joe Rogan Experience?. His show is raw and uncut, with some really out there, yet incredible life advice which is shared by Joe and his mix mash of guests every week.

Joe Rogan?endorses a new supplement brand called ?Onnit? who have proven to deliver great results for their customers. Not sure how much kickback?Joe Rogan?gets for endorsing the Onnit brand but it would be a great idea for anyone who has a large number of listeners to contact some brands who relate to your audience for sponsorship.

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Kevin Kastner PodcastKevin Kastner, no not the actor, but a guy who podcasts the well known ?Alaska TV? once broadcasted via a podcasting network. Networks provide a modicum of security by reaching a broader listening audience; however, Kastner was dissatisfied with splitting his profits with the network. He decided to break away from the network, seek his own sponsors, and keep the earnings. His efforts were successful, as his earnings spiked more than 200% in the first year.

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Royce Hildreth PodcastRoyce Hildreth, who co-produces a podcast which is of interest to pregnant women, utilizes a system that is more or less a hybrid of the network vs. self-sponsored arrangements.

He has an arrangement with a media company where he can solicit his own sponsors, and the media company will take care of inserting the ads for him. This is done on a flat-fee basis, which Hildreth stated has worked out well.

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Don McAllister PodcastDon McAllister, who podcasts ?ScreenCastsOnline?, believes his system is among the best. He provides some podcasts free, and charges a flat fee (usually around $55) for the others.

The free podcasts serve as ?teasers? which generate the interest in the paid broadcasts.

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In Summary

The above tips and techniques are only highlights of podcasting for fun or profit. As long as the broadcaster is passionate and knowledgeable about the material being podcasted, the rest is easy.

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Article By: Joel Brown | Addicted2Success.com

Feature Image Credit: Zoomlar

Source: http://addicted2success.com/success-advice/6-ways-to-create-a-world-famous-money-making-podcast/

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patsyiskul: junal.singh: Forbes Travel Guide City Guides Hit ...

New York, NY (PRWEB) April 7, 2010

With travelers looking for variety, value and an ?Insider?s Edge? in planning their 2010 Summer vacations, Forbes Travel Guide announced that its new City Guides series is available at major bookstores across the country and online.

Authored by Forbes Travel Guide ? formerly Mobil Travel Guide, the originator of the prestigious Mobil Star ratings, certifications and authoritative reviews of hotels, restaurants and spas -, the new City Guides cover New York, Los Angeles, San Francisco, Las Vegas, Chicago and Hong Kong.

Each Guide is a comprehensive resource for prospective visitors to a major urban destination, including shopping, art, music, sports, theater, and nightlife. With the ?inside scoop? from anonymous inspectors and top-notch local writers, the guidebooks use Forbes? time-tested, star-rating system to allow travelers to experience the very best a city has to offer, with planning tools that include updated maps with pinpoints of star-rated properties, key sites, top attractions, quick tips and insider secrets.

?For Summer 2010, it?s all about value and variety,? said Shane O?Flaherty, President and CEO of Forbes Travel Guide.

He concluded, ?Increasingly, individual travelers, couples and families are looking for the diversity and flavor of major urban destinations when planning their leisure time travel ? and we are pleased to make available a series of unmatched resources to help them research and make their travel decisions.?

Forbes Travel Guide expects to release additional City Guides later in 2010.

ABOUT THE CITY GUIDES

Each City Guide contains close to 200 pages of information-packed narrative, photographs and insider perspectives that are based on Forbes Travel Guide?s star rating system that has been the most trusted source for travelers since 1958. The information-packed Guides help direct travelers to the finest lodgings, restaurants, and attractions a city has to offer, making an otherwise daunting task ? planning a visit to a major international destination ? a lively, entertaining and enjoyable experience. Colorfully written and illustrated, each Guide comes in a handy pocket-size format, making it an ideal travel companion for the trip.

The Guides are available at Borders, Barnes & Noble, Amazon.com, Waldenbooks, Books A Million, and most major booksellers/independent book stores.

For more information about the Guides, please visit any of these retail outlets, or learn more at http://www.forbestravel.guide.com

ABOUT FORBES TRAVEL GUIDE

Forbes Travel Guide, formerly Mobil Travel Guide, originator of the prestigious Mobil Star ratings and certifications, has provided the most comprehensive ratings and reviews of hotels, restaurants and spas since 1958.

In October 2009, Mobil Travel Guide announced a strategic partnership with Forbes Media LLC. This exclusive licensing agreement between two industry leaders with more than 140 years of combined experience transfers the hospitality industry?s premier star rating and travel guide brand from ExxonMobil to Forbes. Forbes Travel Guide has a team of expert inspectors who anonymously evaluate properties against rigorous and objective proprietary standards, providing consumers the insight to make better-informed travel and leisure decisions.

ABOUT FORBES MEDIA LLC

Forbes Media encompasses Forbes and Forbes.com, the #1 business site on the Web that reaches on average more than 17 million people monthly. The company publishes Forbes and Forbes Asia, which together reach a worldwide audience of more than 6 million readers. It also publishes ForbesLife and ForbesWoman magazines, in addition to licensee editions in China, Croatia, India, Indonesia, Israel, Korea, Poland, Romania, Russia and Turkey.

Other Forbes Media Web sites are: Investopedia.com; RealClearPolitics.com; RealClearMarkets.com; RealClearSports.com; and the Forbes.com Business and Finance Blog Network. Together with Forbes.com, these sites reach on average nearly 40 million business decision makers each month.

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Tags: Amazon.com, Bookstores, City, Forbes, Guide, Guides, Just, Planning, Summer, Time, Travel

Source: http://harikemerdekaan.id1945.com/forbes-travel-guide-city-guides-hit-bookstores-and-amazon-com-just-in-time-for-summer-travel-planning/

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Source: http://junalsingh9.blogspot.com/2013/01/forbes-travel-guide-city-guides-hit.html

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Source: http://patsyiskul.blogspot.com/2013/01/junalsingh-forbes-travel-guide-city.html

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Mass Human Sacrifice? Pile of Ancient Skulls Found

Archaeologists have unearthed a trove of skulls in Mexico that may have once belonged to human sacrifice victims. The skulls, which date between A.D. 600 and 850, may also shatter existing notions about the ancient culture of the area.

The find, described in the January issue of the journal Latin American Antiquity, was located in an otherwise empty field that once held a vast lake, but was miles from the nearest major city of the day, said study co-author Christopher Morehart, an archaeologist at Georgia State University.

"It's absolutely remarkable to think about this little nothing on the landscape having potentially evidence of the largest mass human sacrifice in ancient Meso-America," Morehart said.

Middle of nowhere

Morehart and his colleagues were using satellite imagery to map ancient canals, irrigation channels and lakes that used to surround the kingdom of Teotihuacan (home to the Pyramid of the Sun), about 30 miles (50 kilometers) from Mexico City. The vast ancient kingdom flourished from around A.D 200 to 650, though who built it remains a mystery. [In Photos: Amazing Ruins of the Ancient World]

In a now drained lake called Lake Xaltocan, around which was essentially rural farmland at the time, Morehart stumbled upon a site with evidence of looting.

When the team investigated, they discovered lines of human skulls with just one or two vertebra attached. To date, more than 150 skulls have been discovered there. The site also contained a shrine with incense burners, water-deity figurines and agricultural pottery, such as corncob depictions, suggesting a ritual purpose tied to local farming. [See images from the grisly excavation ]

Carbon dating suggested that the skulls were at least 1,100 years old, and the few dozen analyzed so far are mostly from men, Morehart told LiveScience. The researchers did not release photos of the skulls because the sacrifice victims may have historic ties to modern-day indigenous cultures.

The findings shake up existing notions of the culture of the day, because the site is not associated with Teotihuacan or other regional powers, said Destiny Crider, an archaeologist at Luther College in Iowa, who was not involved in the study.

Human sacrifice was practiced throughout the region, both at Teotihuacan and in the later Aztec Empire, but most of those rituals happened at great pyramids within cities and were tied to state powers.

By contrast, "this one is a big event in a little place," Crider said.

The shrines and the fact that sacrifice victims were mostly male suggest they were carefully chosen, not simply the result of indiscriminate slaughter of a whole village, Crider told LiveScience.

Many researchers believe that massive drought caused the fall of Teotihuacan and ushered in a period of warfare and political infighting as smaller regional powers sprang up, Morehart said.

Those tumultuous times could have spurred innovative ? and bloody ? practices, Crider said.

"Maybe they needed to intensify their activities because everything was changing," she said. "When things are uncertain you try new strategies."

Follow LiveScience on Twitter @livescience. We're also on Facebook?& Google+.?

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Saturday, January 26, 2013

McDonough no stranger to Obama inner circle

WASHINGTON (AP) ? In selecting Denis McDonough to be his next and fifth chief of staff, President Barack Obama is tapping a longtime confidant and unflappable ally to be his gatekeeper to the personalities and challenges that will confront him in his second term.

Obama announced Friday that McDonough, now one of the president's closest national security advisers, will replace outgoing White House chief of staff Jack Lew, whom Obama has nominated for the treasury secretary.

McDonough, 43, becomes the latest link in a chain of staffers elevated to key roles in the Obama White House following years of service within the president's closely guarded inner circle. The risk-averse strategy keeps Obama in his comfort zone and ensures that those setting the tone for the administration are in tight harmony with his way of thinking.

"The president trusts him ? perhaps more than anyone else in the White House. And I think he knows the president's mind perhaps better than anyone else in the White House," said John Podesta, who served as President Bill Clinton's chief of staff and co-chaired Obama's transition team. Podesta worked closely with McDonough both in former Sen. Tom Daschle's office and at the Center for American Progress, a think tank with close ties to the White House.

A native of Stillwater, Minn., McDonough obtained a master's degree from Georgetown University in 1996 and soon became a foreign policy staffer in the House, then later in the Senate under Daschle, the top Senate Democrat at the time. Like so many of the president's senior aides, his work for Obama started during the 2008 campaign, where he served as a foreign policy aide and was a senior adviser on the transition team. In 2009, he became the chief of staff for Obama's national security staff.

Announcing his choice on Friday in the White House, Obama said McDonough was not only one of his closest advisers but also one of his closest friends, recounting the "countless crises" during the first term that had engrossed McDonough at all hours of the day.

"I've actually begun to think that Denis likes pulling all-nighters," Obama said to knowing laughter from fellow staffers in the East Room. "The truth is nobody outworks Denis McDonough."

Current and former White House staffers describe McDonough as an exceptionally hard worker with deep loyalty to the president. Highly regarded by fellow White House staffers, McDonough has a deep well of experience navigating tough national security issues; he is among the top officials photographed with Obama in the situation room in 2011 as Navy SEALs carried out the raid that killed Osama bin Laden.

But McDonough is also known for putting a human touch on his demanding job, occasionally sending handwritten thank-you notes to co-workers for their help on projects or foreign trips.

"You often find in Washington people very skillful on substance. You have very good people on the politics of people. It's a fairly rare staffer who combines the two," said former Rep. Lee Hamilton, D-Ind., who employed McDonough as a foreign policy adviser in the 1990s and described his demeanor as calm and reasonable. "Firm, commanding in a sense. He had command of the facts without being offensive in any way."

That's important, because Obama has made no secret of his preference for a low-key work environment, free of the drama and clash of personalities that can so often distract from the pursuit of a policy agenda.

Obama's first chief of staff, current Chicago Mayor Rahm Emanuel, was known more for volatility than cool-headedness. And some administration officials still bristle at the president's attempt to bring in an outsider for the chief of staff job ? Bill Daly, who replaced Emanuel but only lasted about a year before leaving Washington. McDonough is expected to be more in the mold of Lew, the even-keeled budget guru who, like McDonough, had already amassed a lengthy Washington resume before becoming Obama's chief of staff.

But what McDonough boasts in foreign policy expertise he lacks when it comes to domestic policy, which encompasses the bulk of the major issues the president will confront as his second term gets under way. Looming over the start of McDonough's term as chief of staff are a set of fiscal showdowns over debt and government spending, a heated campaign for gun control legislation and a major push for comprehensive immigration reform.

Although McDonough's portfolio has been national security, he is involved in daily senior staff meetings at the White House that often focus on domestic issues. Last year, when the White House was embroiled in an internal debate over a mandate requiring religious organizations to offer contraception coverage, McDonough, a Catholic and one of 11 children, was among a handful of aides who raised concerns.

Obama is expected to surround McDonough with aides who have broader experience on domestic issues and congressional negotiations ? most notably Rob Nabors, Obama's legislative director and chief negotiator with Capitol Hill, who the president tapped Friday to become his new deputy chief of staff for policy.

"He does not have the kind of background that Jack Lew had in budget matters, so he'll have to bring on board some very knowledgeable people," said Hamilton. "He probably already has."

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AP White House Correspondent Julie Pace contributed to this report.

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Reach Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Source: http://news.yahoo.com/mcdonough-no-stranger-obama-inner-circle-173755618--politics.html

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